A “Living” Microvascular Stamp: “Living” Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry (Adv. Mater. 1/2012)

Abstract

Orchestrated control of matrix property and geometry is reported by Rashid Bashir, Hyunjoon Kong, and co-workers on page 58. The “living” microvascular stamp releases multiple angiogenic factors and subsequently creates functional neo-vessels with the same pattern as that engraved in the stamp. The stamp consists of live cells that secrete angiogenic factors, an engineered hydrogel matrix that promotes cellular expression of angiogenic factors, and a three-dimensional geometry that localizes the angiogenic factors within the pattern.