Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in <i>Drosophila melanogaster</i>

William C. Orr, Rajindar S. Sohal · Science · 1994 · 1.5K citations

Life Sciences, Entomology, Genetics +17

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

César G. Fraga, Mark K. Shigenaga, J W Park et al. · Proceedings of the National Academy of Sciences · 1990 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +16

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Rajindar S. Sohal, Hung‐Hai Ku, Sanjiv Agarwal et al. · Mechanisms of Ageing and Development · 1994 · 788 citations

Life Sciences, Biochemistry, Nutritional Sciences +17

Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.

Ramesh C. Gupta · Proceedings of the National Academy of Sciences · 1984 · 520 citations · Full text

Pharmacy, Molecular Biology, Toxicology +14

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

Hung‐Hai Ku, Ulf T. Brunk, Rajindar S. Sohal · Free Radical Biology and Medicine · 1993 · 487 citations

Life Sciences, Biology, Cell Biology +16