The effects of Ginkgo biloba extract on lipopolysaccharide-induced inflammation in vitro and in vivo

Endotoxin-induced uveitis in rats as a model for human disease

James T. Rosenbaum, H O McDevitt, R. B. Guss et al. · Nature · 1980 · 556 citations

Medicine, Immunology, Pathobiology +14

Effects of Astaxanthin on Lipopolysaccharide-Induced Inflammation In Vitro and In Vivo

Kazuhiro Ohgami, Kenji Shiratori, Satoshi Kotake et al. · Investigative Ophthalmology & Visual Science · 2003 · 305 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma

Luciano Quaranta, S. Bettelli, Maurizio G. Uva et al. · Ophthalmology · 2003 · 197 citations

Medicine, Ophthalmology, Vision Science +6

Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat.

Alex F. de Vos, Vincent N. A. Klaren, Aize Kijlstra · PubMed · 1994 · 170 citations

Medicine, Immunology, Ophthalmology +17

Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α 1 1Abbreviations: EGb 761, Ginkgo biloba extract; LPS, lipopolysaccharide; ROIs, reactive oxygen intermediates; TNF, tumor necrosis factor; IL, interleukin; COX, cyclooxygenase; iNOS, inducible nitric oxide synthase; TLR, Toll-like receptor; LBP, lipid binding protein; NF-κB, nuclear factor-κB; IKK, IκB kinase; AP-1, activator protein 1; ATF, activating transcription factor; CRE, cyclic AMP response element; CREB, cyclic AMP binding protein; C/EBP, CCAAT/enhancer binding protein; ARE, AU-rich element; -UTR, untranslated region; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-related kinase; MEKK, MAPK/ERK kinase kinase; MEK, MAPK/ERK kinase; JNK/SAPK, Jun N terminal kinase/stress-activated protein kinase; EMSA, electrophoretic mobility shift assay; DTT, dithiothreitol; PMSF, phenylmethylsulfonyl fluoride; and ECL, enhanced chemiluminescence.

Teri L. Wadsworth, T.L. McDonald, Dennis R. Koop · Biochemical Pharmacology · 2001 · 145 citations

Life Sciences, Immunology, Pharmacology +17