Increased Risk of Anastomotic Leakage with Diclofenac Treatment after Laparoscopic Colorectal Surgery

Abstract

We found an increased number of clinically significant anastomotic leakages in patients receiving oral diclofenac for postoperative analgesia. There is an urgent need to test our hypothesis in prospective randomized clinical trials and to examine whether our findings can be extended to open surgery and to other NSAIDs.