Receptor coupling to polyphosphoinositide turnover: a parallel with the adenylate cyclase system

Inositol trisphosphate, a novel second messenger in cellular signal transduction

Michael J. Berridge, Robin F. Irvine · Nature · 1984 · 6.1K citations

Signal Transduction, Biochemistry, Natural Sciences +9

G proteins and dual control of adenylate cyclase

Alfred G. Gilman · Cell · 1984 · 1.8K citations

Biochemistry, G Protein-coupled Receptor, Natural Sciences +2

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

Irene Litosch, Cleatus J. Wallis, John N. Fain · Journal of Biological Chemistry · 1985 · 430 citations · Full text

Cellular Physiology, Receptor Mechanism, Neuroendocrine Mechanism +20

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

Fumikazu Okajima, M Ui · Journal of Biological Chemistry · 1984 · 388 citations · Full text

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

Ronald J. Uhing, Veronica Prpić, Hang Jiang et al. · Journal of Biological Chemistry · 1986 · 375 citations · Full text