Effects of the farnesyl transferase inhibitor R115777 on normal and leukemic hematopoiesis

BindingDB Entry 2025: Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

PubMed · 2007 · 462 citations · Full text

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

Judith E. Karp, Jeffrey E. Lancet, Scott H. Kaufmann et al. · Blood · 2001 · 445 citations · Full text

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

Laura Sepp‐Lorenzino, Zhuang Ma, Elaine Rands et al. · PubMed · 1995 · 384 citations

Chemoprevention Strategy, Protein Transferase, Cancer Biology +17

Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer

J. Zujewski, Ivan D. Horak, C.J. Bol et al. · Journal of Clinical Oncology · 2000 · 265 citations

Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells

HJ Sutherland, CJ Eaves, PM Lansdorp et al. · Blood · 1991 · 245 citations · Full text