Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1α and VEGF expression in non-small cell lung cancer cells

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Role of angiogenesis in tumor growth and metastasis

J Folkman · Seminars in Oncology · 2002 · 2.4K citations

Medicine, Cancer Biology, Oncology +12

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

Eric Huang, Jie Gu, Maureen Schau et al. · Proceedings of the National Academy of Sciences · 1998 · 2.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

John Brognard, Amy S. Clark, Yucheng Ni et al. · PubMed · 2001 · 892 citations

Medicine, Cancer Biology, Oncology +17

Interleukin-17 promotes angiogenesis and tumor growth

M. Numasaki · Blood · 2002 · 810 citations · Full text

Medicine, Immunology, Oncology +14