Concepedia

Liver and intestinal lactate metabolism in patients with acute hepatic failure undergoing liver transplantation

Nick Murphy, Sadik K. Kodakat, Julia Wendon, C. A. Jooste, Paolo Muiesan, Mohamed Rela, Nigel Heaton

Critical Care Medicine · 2001 · 99 citations · 32 references

DOI

Abstract

The liver is a net producer of lactate in patients with ALF and an elevated whole blood lactate. After liver transplantation, the graft becomes a consumer of lactate as shown by the negative lactate gradient. The degree of consumption is dependent on portal venous lactate concentration and cold ischemic time.

References

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