The μ rather than the δ subtype of opioid receptors appears to be involved in enkephalin-induced analgesia

Individual Comparisons by Ranking Methods

Frank Wilcoxon · Biometrics Bulletin · 1945 · 14.4K citations

Business, Computer Science, Multi-criteria Decision Making +8

A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS

J.T. LITCHFIELD, Frank Wilcoxon · Journal of Pharmacology and Experimental Therapeutics · 1949 · 7.3K citations

Public Health, Biostatistics, Pharmacology +12

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9