Transcriptional modulation of BCRP gene to reverse multidrug resistance by toremifene in breast adenocarcinoma cells

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

Keisuke Miyake, Lyn A. Mickley, Thomas Litman et al. · PubMed · 1999 · 822 citations · Full text

Medicine, Molecular Biology, Oncology +14

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

R Allikmets, Lynn M. Schriml, Amy Hutchinson et al. · PubMed · 1998 · 800 citations

Life Sciences, Genetics, Molecular Genetics +14

The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

Thomas Litman, Mariafiorella Brangi, Eric A. Hudson et al. · Journal of Cell Science · 2000 · 534 citations · Full text

Medicine, Oncology, Pharmacology +17

Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.

Marc Maliepaard, M A van Gastelen, L A de Jong et al. · PubMed · 1999 · 487 citations

Medicine, Cancer Biology, Cancer Pharmacology +12

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

John Allen, R F Brinkhuis, Jan Wijnholds et al. · PubMed · 1999 · 352 citations

Medicine, Oncology, Pharmacology +17