New insights into early sequential PrPsc accumulation in scrapie infected mouse brain evidenced by the use of streptomycin sulfate

Novel Proteinaceous Infectious Particles Cause Scrapie

Stanley B. Prusiner · Science · 1982 · 5.1K citations

Veterinary Medicine, Infectious Diseases, Molecular Biology +10

Identification of a Protein That Purifies with the Scrapie Prion

David C. Bolton, Michael P. McKinley, Stanley B. Prusiner · Science · 1982 · 1.3K citations

Life Sciences, Biochemistry, Molecular Biology +14

Cell-free formation of protease-resistant prion protein

David A. Kocisko, Jon H. Come, Suzette A. Priola et al. · Nature · 1994 · 880 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

Stanley B. Prusiner, Michael Scott, Dallas Foster et al. · Cell · 1990 · 869 citations

Life Sciences, Genetics, Molecular Biology +15

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

Glenn C. Telling, Michael Scott, James A. Mastrianni et al. · Cell · 1995 · 850 citations · Full text

Veterinary Medicine, Genetics, Molecular Biology +14