Concepedia

The Total Synthesis of (±)-11-<i>O</i>-Debenzoyltashironin

Silas P. Cook, Alessandra Polara, Samuel J. Danishefsky

Journal of the American Chemical Society · 2006 · 106 citations · 14 references

DOI

Concepts

Abstract

The total synthesis of the putative non-peptidyl neurotrophic factor 11-O-debenzoyltashironin has been accomplished. The key transformation involves a biomimetic oxidative dearomatization/transannular Diels-Alder sequence that closes the tetracyclic carbon skeleton present in the natural product.

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