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Development and validation of a gas chromatography–mass spectrometry method for the simultaneous determination of buprenorphine, flunitrazepam and their metabolites in rat plasma: application to the pharmacokinetic study

Pharmacological StudyMedicineMass SpectrometryPharmacokinetic StudyAnalytical ChemistrySimultaneous DeterminationMetabolomicsChromatographyPharmacologyRat PlasmaPharmacokineticsPharmacodynamic ModelingAnesthesiologyDrug Analysis