Concepedia

IL-1Ra selectively protects intestinal crypt epithelial cells, but not tumor cells, from chemotoxicity via p53-mediated upregulation of p21WAF1 and p27KIP1

Xia Wang, Shunying Zhu, Lan Qian, Jing Gao, Mingyuan Wu, Jin Gao, Yang Zhang, Gerald L. Chan, Yan Yu, Wei Han

Pharmacological Research · 2014 · 20 citations · 39 references

DOI

Concepts

References

39

WAF1, a potential mediator of p53 tumor suppression

Wafik S. El‐Deiry, Takashi Tokino, Victor E. Velculescu et al. · Cell · 1993 · 8.4K citations

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Biologic basis for interleukin-1 in disease

CA Dinarello · Blood · 1996 · 4.4K citations · Full text

, , +12

p21 is a universal inhibitor of cyclin kinases

Yue Xiong, Gregory J. Hannon, Hui Zhang et al. · Nature · 1993 · 3.4K citations

, , +14

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

Hideo Toyoshima, Tony Hunter · Cell · 1994 · 2.1K citations

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

Hazel Cheng, C. P. Leblond · American Journal of Anatomy · 1974 · 1.7K citations

, , +13