Adriamycin(hydrazone)-antibody conjugates require internalization and intracellular acid hydrolysis for antitumor activity

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

Colin R. Hopkins, Ian S. Trowbridge · The Journal of Cell Biology · 1983 · 633 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

Thomas R. Triton, Gene K. Yee · Science · 1982 · 572 citations

Medicine, Oncology, Pharmacology +8

Anti-Cancer Drug Design

Michael W. Moore · British Journal of Cancer · 1985 · 398 citations · Full text

Evaluation in vitro of adriamycin immunoconjugates synthesized using an acid-sensitive hydrazone linker.

Robert S. Greenfield, Takushi Kaneko, A Daues et al. · PubMed · 1990 · 179 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Doxorubicin conjugated with a monoclonal antibody directed to a human melanoma-associated proteoglycan suppresses the growth of established tumor xenografts in nude mice.

Hua Yang, R. Reisfeld · Proceedings of the National Academy of Sciences · 1988 · 151 citations · Full text

Pharmacy, Oncology, Pharmacology +16