Concepedia

Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)

David J. Witter, Paul E. Harrington, Kevin J. Wilson, Mélissa Chénard, Judith C. Fleming, Brian B. Haines, Astrid M. Kral, J. Paul Secrist, Thomas A. Miller

Bioorganic & Medicinal Chemistry Letters · 2007 · 95 citations · 11 references

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11

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Michael S. Finnin, Jill R. Donigian, Alona Cohen et al. · Nature · 1999 · 1.7K citations

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Alessandro Vannini, Cinzia Volpari, Gessica Filocamo et al. · Proceedings of the National Academy of Sciences · 2004 · 627 citations · Full text

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Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

Ping Zhu, Elke Martin, Jörg Mengwasser et al. · Cancer Cell · 2004 · 535 citations · Full text

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HDAC inhibitors: Clinical update and mechanism-based potential

Keith B. Glaser · Biochemical Pharmacology · 2007 · 349 citations

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A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Santiago Ropero, Mario F. Fraga, Esteban Ballestar et al. · Nature Genetics · 2006 · 292 citations

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