Antiplatelet effects of piplartine, an alkamide isolated from<i>Piper tuberculatum</i>: possible involvement of cyclooxygenase blockade and antioxidant activity

Abstract

The mechanism underlying the piplartine antiplatelet action is not totally clarified. It could be related to the inhibition of cyclooxgenase activity and a decrease in thromboxane A(2) formation, similar to that occurring with aspirin. This and other possible mechanisms require further study.