Model Complexes of the Active Site in Peptide Deformylase:  A New Family of Mononuclear N₂S−M(II) Complexes

Abstract

A new tridentate N2Sthiolate ligand, PATH, has been prepared and includes a sterically hindered aliphatic thiolate donor as a cysteine mimic. PATH was employed in the synthesis of the monomeric complexes [(PATH)MIIBr] and [(PATH)MIINCS] (M = Zn, Co), which have been characterized by X-ray diffraction. These complexes are close structural analogues of the His2Cys site found in peptide deformylase.