Activation of the unfolded protein response in Parkinson’s disease

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Mihael H. Polymeropoulos, Christian Lavedan, Elisabeth Leroy et al. · Science · 1997 · 8.2K citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Heather P. Harding, Yuhong Zhang, David Ron · Nature · 1999 · 3.2K citations

Protein Function, Signal Transduction, Protein Folding +6

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Heather P. Harding, Isabel Novoa, Yuhong Zhang et al. · Molecular Cell · 2000 · 3.2K citations · Full text

Transcriptional Regulation, Developmental Biology, Cell Regulation +7

α-synuclein locus duplication as a cause of familial Parkinson's disease

Marie‐Christine Chartier‐Harlin, Jennifer M. Kachergus, Christophe Roumier et al. · The Lancet · 2004 · 2K citations

Neurodegenerative Diseases, Mendelian Disorder, Degenerative Diseases +11

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo et al. · Nature Genetics · 2000 · 2K citations

Ubiquitin-protein Ligase, Mendelian Disorder, Genetics +5