Gene conversion events between <i><scp>GYPB</scp></i> and <i><scp>GYPE</scp></i> abolish expression of the <scp>S</scp> and s blood group antigens

Abstract

The three GYPB-E-B hybrid genes reported here constitute the first evidence of recombination events between GYPB and GYPE. As these GYPB-E-B hybrid genes drive the S-s- blood phenotype, it is important to know they are a limitation for the current blood group genotyping methods, including those performed by commercial platforms.