Chrysanolide A, an unprecedented sesquiterpenoid trimer from the flowers of Chrysanthemum indicum L

Abstract

Chrysanolide A, a novel guaianolide-type sesquiterpenoid trimer (3), along with its biogenetically related monomer (Chrysanolide B, 1) and dimer (Chrysanolide C, 2), were simultaneously isolated from Chrysanthemum indicum L flowers. Their structures and absolute configurations were elucidated via spectroscopic and computational methods. All isolated compounds were evaluated for their anti-HBV activities.