In vitro and in vivo effects of leflunomide, Brequinar, and cyclosporine on pyrimidine biosynthesis

The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase

June P. Davis, Gary A. Cain, William J. Pitts et al. · Biochemistry · 1996 · 294 citations

Medicine, Biochemistry, Pharmacology +13

Inhibition of Protein Tyrosine Phosphorylation in T Cells by a Novel Immunosuppressive Agent, Leflunomide

Xiulong Xu, James W. Williams, Eric G. Bremer et al. · Journal of Biological Chemistry · 1995 · 218 citations · Full text

Medicine, Immunology, Pharmacology +17

Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide

Sharon K. Greene, Kiyotaka Watanabe, Julie Braatz-Trulson et al. · Biochemical Pharmacology · 1995 · 197 citations

Life Sciences, Biochemistry, Pharmacology +11

Dihydroorotate Dehydrogenase Is a High Affinity Binding Protein for A77 1726 and Mediator of a Range of Biological Effects of the Immunomodulatory Compound

Richard A. Williamson, Christopher Yea, P.A. Robson et al. · Journal of Biological Chemistry · 1995 · 197 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

REGULATION OF B CELL FUNCTION BY THE IMMUNOSUPPRESSIVE AGENT LEFLUNOMIDE1

Karyn F. Siemasko, Anita S. Chong, James W. Williams et al. · Transplantation · 1996 · 186 citations

Life Sciences, Immunology, Pharmacology +15