Concepedia

Qualification of a homogeneous cell-based neonatal Fc receptor (FcRn) binding assay and its application to studies on Fc functionality of IgG-based therapeutics

Abhishek Mathur, Taruna Arora, Ling Liu, Jill Crouse-Zeineddini, Venkat R. Mukku

Journal of Immunological Methods · 2013 · 21 citations · 24 references

DOI

Concepts

References

24

Enhanced antibody half-life improves in vivo activity

Jonathan Zalevsky, Aaron K. Chamberlain, Holly M. Horton et al. · Nature Biotechnology · 2010 · 644 citations · Full text

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Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

William F. Dall’Acqua, Peter A. Kiener, Herren Wu · Journal of Biological Chemistry · 2006 · 637 citations · Full text

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Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies

Raimund J. Ober, Caius G. Radu, Victor Gheţie et al. · International Immunology · 2001 · 494 citations

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Crystal structure of the complex of rat neonatal Fc receptor with Fc

Andrew H. Huber, Pamela J. Björkman · Nature · 1994 · 432 citations

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Crystal Structure at 2.8 Å of an FcRn/Heterodimeric Fc Complex

Warham Lance Martin, Anthony P. West, Lu Gan et al. · Molecular Cell · 2001 · 386 citations · Full text

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