Concepedia

Antiulcer effect of flavonoids. Role of endogenous PAF

Angelo A. Izzo, Giulia Di Carlo, Nicola Mascolo, Francesco Capasso, Giuseppina Autore

Phytotherapy Research · 1994 · 100 citations · 20 references

DOI

Concepts

Abstract

Abstract Quercetin, rutin and kaempferol, administered intraperitoneally (25–100 mg/kg) inhibited dose‐dependently gastric damage produced by acidified ethanol in rats. Flavone was inactive while naringin was active at higher dose (200 mg/kg). The flavonols tested inhibited dose‐dependently the mucosal content of platelet‐activating factor (PAF) suggesting that the protective effects of these substances may be mediated by endogenous PAF.

References

20

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Sándor Szabó, Jerry S. Trier, A. Brown et al. · Gastroenterology · 1985 · 479 citations

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Studies on the mechanism of ethanol-induced gastric damage in rats

Peter J. Oates, John P. Hakkinen · Gastroenterology · 1988 · 371 citations · Full text

, , +4

Selectivity of Neutrophil 5-Lipoxygenase and Cyclo-oxygenase Inhibition by an Anti-inflammatory Flavonoid Glycoside and Related Aglycone Flavonoids

M.A. Moroney, M. José Alcaraz, Robert A. Forder et al. · Journal of Pharmacy and Pharmacology · 1988 · 325 citations

, , +23

Inhibition of Intestinal Motility and Secretion by Flavonoids in Mice and Rats: Structure-activity Relationships

Giulia Di Carlo, Giuseppina Autore, Angelo A. Izzo et al. · Journal of Pharmacy and Pharmacology · 1993 · 270 citations

, , +13

Potent ulcerogenic actions of platelet-activating factor on the stomach

Ann-Charlotte Rosam, John L. Wallace, Brendan J.R. Whittle · Nature · 1986 · 247 citations

, , +6