Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate.

Peter E. Thorsness, Daniel E. Koshland · Journal of Biological Chemistry · 1987 · 310 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Brain 14‐3‐3 protein is an activator protein that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca²⁺,calmodulin‐dependent protein kinase II

Tohru Ichimura, Toshiaki Isobe, Tsueno Okuyama et al. · FEBS Letters · 1987 · 293 citations

Life Sciences, Biochemistry, Neuroscience +17

Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.

Tong H. Joh, D.H. Park, D.J. Reis · Proceedings of the National Academy of Sciences · 1978 · 286 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.

John W. Haycock, Natalie G. Ahn, Melanie H. Cobb et al. · Proceedings of the National Academy of Sciences · 1992 · 262 citations

Life Sciences, Biochemistry, Neuroscience +16