The Half-Life of 2-Chloroprocaine

Abstract

The purpose of this study was to examine the discrepancy between the reported in vitro half-life of chloroprocaine and the slower observed disappearance of the drug in maternal plasma. The study had two aims. The first was to redetermine the in vitro half-life of 2-chloroprocaine in maternal and fetal plasma. The second was to determine the apparent half-life of 2-chloroprocaine in vivo after intrapartum epidural anesthesia in obstetric patients. Gas chromatography or gas chromatography/mass spectrometry techniques were used to measure 2-chloroprocaine in maternal or fetal plasma. Mean in vitro half-lives of 11.2 +/- 2.8 and 15.4 +/- 5.2 sec were found for maternal and fetal plasma from nine patients, respectively. The maternal half-life was significantly shorter than the fetal half-life (P less than 0.05). The mean apparent in vivo half-life in maternal plasma was found to be 3.1 +/- 1.6 min. The results of this study show that the half-life in vitro is correctly measured in seconds. However, the apparent half-life in vivo after epidural anesthesia is 3.1 +/- 1.6 min and ranges from 1.5 to 6.4 min. The differences in the magnitude of the two findings is probably due to continuous uptake of the drug from the epidural space.