THE EFFECT OF NICOTINE ON ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY IN A MOUSE MODEL OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

Stephen J. Davis, Valeriy V. Lyzogubov, Ruslana G. Tytarenko, Ammar Safar, Nalini S. Bora, Puran S. Bora

Retina · 2011 · 20 citations · 29 references

DOIFull text

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Abstract

Nicotine significantly blocks the effect of anti-vascular endothelial growth factor therapy in the treatment of laser-induced neovascular age-related macular degeneration. nAChRα7 is significantly upregulated during the formation of CNV, and treatment with an nAChRα7 antagonist decreases CNV size irrespective of nicotine administration.

References

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