<i>In Vitro</i> Human Scleral Permeability of Fluorescein, Dexamethasone-Fluorescein, Methotrexate-Fluorescein and Rhodamine 6G and the Use of a Coated Coil as a New Drug Delivery System

Abstract

The rank order of scleral permeability to the studied dyes is as follows: fluorescein > methotrexate-fluorescein > rhodamine coil > rhodamine 6G > dexamethasone-fluorescein. Differences in scleral permeability are related to MW and lipid solubility. Prolonged transscleral diffusion of rhodamine delivered by solution and by coil are similar.