Inactivation of the Deubiquitinase CYLD in Hepatocytes Causes Apoptosis, Inflammation, Fibrosis, and Cancer

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

Ittai Ben‐Porath, Matthew Thomson, Vincent J. Carey et al. · Nature Genetics · 2008 · 2.5K citations · Full text

Developmental Biology, Medicine, Aggressive Human Tumors +8

NF-κB functions as a tumour promoter in inflammation-associated cancer

Eli Pikarsky, Rinnat M. Porat, Ilan Stein et al. · Nature · 2004 · 2.4K citations

Inflammation, Medicine, Immunology +7

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Hideaki Kamata, Shinichi Honda, Shin Maeda et al. · Cell · 2005 · 1.8K citations · Full text

Inflammation, Redox Signaling, Signal Transduction +12

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

Joachim Rothe, Werner Lesslauer, Hansruedi Lötscher et al. · Nature · 1993 · 1.3K citations

Inflammation, Cytokine, Host Response +9

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

Shin Maeda, Hideaki Kamata, Jun‐Li Luo et al. · Cell · 2005 · 1.2K citations · Full text

Inflammation, Signal Transduction, Hepatology +13