Experimental & Molecular Medicine · 2004 · 45 citations · 6 references
Life SciencesGeneticsImmunologyAutoimmunityImmunogeneticsMolecular ImmunologyAllergic DiseaseAllergic RhinitisGenetic Susceptibility To AutoimmunityImmune Gene RegulationMucosal ImmunogeneticsT Cell BiologyAllergic Rhinitis ImmunogeneticsGenomic Dna AnalysisPromoter Region IdentificationT-cell Immunoglobulin DomainT-cell Immunoglobulin Domain-containing Protein 3T-cell Mucin Domain-containing Protein 3Th1 Immune ResponseTh1 Responses
The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, Tim-3 (T cell immunoglobulin mucin 3) is selectively expressed on the surface of differentiated Th1 cells. Tim-3 might have an important role in the induction of autoimmune diseases by regulating macrophage activation and interacts with Tim-3 ligand to regulate Th1 responses. To determine the variation sites in the coding and promoter region of human Tim-3 gene, we performed variation scanning by direct sequencing using the genomic DNA isolated from the patients with asthma or allergic rhinitis and healthy controls without asthma and allergic rhinitis. We identified four single nucleotide polymorphisms (SNPs) including one novel SNPs (-1541C>T) and two variation sites (-1292_-1289delTAAA and -1282_-1278dupTAAAA) in the coding and promoter region of human Tim-3 gene in both the patients and healthy groups.
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Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2
Atsushi Kumanogoh, Satoko Marukawa, Kazuhiro Suzuki et al. · Nature · 2002 · 329 citations