Mechanisms involved in the hormonal regulation of mitochondrial function through changes in the matrix volume

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

M Crompton, H Ellinger, A Costi · PubMed · 1988 · 848 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl <i>cis-trans</i> isomerase and preventing it interacting with the adenine nucleotide translocase

Andrew P. Halestrap, A M Davidson · Biochemical Journal · 1990 · 746 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

Kimberly M. Broekemeier, Mary E. Dempsey, Douglas R. Pfeiffer · Journal of Biological Chemistry · 1989 · 697 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

Involvement of the ADPATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: Importance of the orientation of the nucleotide binding site

Khanh Lê-Quôc, Danielle Lê-Quôc · Archives of Biochemistry and Biophysics · 1988 · 183 citations

Life Sciences, Biochemistry, Biophysics +17

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria

J G McCormack · Biochemical Journal · 1985 · 141 citations · Full text

Life Sciences, Biochemistry, Physiology +17