Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors

A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635

Elaine A. Forster, Ian A. Cliffe, David J. Bill et al. · European Journal of Pharmacology · 1995 · 609 citations

Molecular Pharmacology, Biochemistry, Functional Selectivity +8

Arenesulfonate derivatives of homochiral glycidol: versatile chiral building blocks for organic synthesis

Janice M. Klunder, Tetsuo Onami, K. Barry Sharpless · The Journal of Organic Chemistry · 1989 · 189 citations

Derivative (Chemistry), Arenesulfonate Derivatives, Derivatives +13

Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1a receptors that are negatively coupled to adenylate cyclase in permanently transfected hela cells

Petrus J. Pauwels, Paul Van Gompel, Josée E. Leysen · Biochemical Pharmacology · 1993 · 82 citations · Full text

Signal Transduction, Medicine, Receptor (Biochemistry) +7

Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5‐HT_1A autoreceptor <i>in vivo</i>

E. M. Clifford, Sarah E. Gartside, Valerie Umbers et al. · British Journal of Pharmacology · 1998 · 75 citations · Full text

Stimulated [35S]GTPγS binding by 5-HT1A receptor agonists in recombinant cell lines Modulation of apparent efficacy by G-protein activation state

Petrus J. Pauwels, Stéphanie Tardif, Thierry Wurch et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 1997 · 70 citations

Molecular Pharmacology, G-protein Activation State, Signal Transduction +12