Cell · 2007 · 313 citations · 39 references
MedicineCancer BiologyMolecular BiologyMolecular OncologyOncogenesSignal TransductionCellular SenescenceOncogene-induced SenescenceRas Family OncogenesSmall Gtpase SignalingTumor Suppressor Gene InactivationTumor Suppressor GenesOncogenic Ras SignalingRas Signaling PathwaySenescenceTumor Suppression By SenescenceTumor Suppression Mechanisms
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Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text
Medicine, Cell Biology, Oncology +10
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations