EXPERIMENTAL PRODUCTION OF CLINICAL TYPES OF SYPHILIS IN THE RABBIT

Abstract

Syphilis in the human subject is characterized by the occurrence of a succession of lesions of various types which follow one another in a more or less orderly progression from the chancre to the terminal stages of the infection, and while to each period of the infection certain types of lesions have been assigned, the order of their appearance is not entirely fixed nor can one say just what lesions may be expected to occur in a given case. The factors that determine these features of the disease may be numerous, and the results of their action differ so widely that diversity rather than uniformity has come to be recognized as one of the most fundamental characteristics of syphilis. The causes which underly this diversity of clinical types are but little understood. It is of course obvious that there are two sets of factors which may contribute to this condition,