Angewandte Chemie International Edition · 2014 · 109 citations · 49 references
PharmacyOncologyPharmaceuticsDrug DeliveryNanomaterialsNanoparticle Drug DeliveryCancer Drug DeliveryCancer NanomedicineNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsNanoparticle DesignCancer NanotherapyGold Nanoparticle Drug DeliveryMesoporous Silica NanomaterialsMesoporous Silica NanoparticlesReactive Oxygen Species GenerationRedox BalanceSelectivitySilica-based Nanoparticles
Construction of delivery systems for anticancer gold complexes to decrease their toxicity while maintaining efficacy is a key strategy to optimize and develop anticancer gold medicines. Herein, we describe cancer-targeted mesoporous silica nanoparticles (MSN) for delivery of a gold(III) porphyrin complex (Au-1 a@MSN(R)) to enhance its anticancer efficacy and selectivity between cancer and normal cells. Encapsulation of Au-1 a within mesoporous silica nanoparticles amplifies its inhibitory effects on thioredoxin reductase (TrxR), resulting in a loss of redox balance and overproduction of reactive oxygen species (ROS). Elevated cellular oxidative stress activates diversified downstream ROS-mediated signaling pathways, leading to enhanced apoptosis-inducing efficacy.
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A New Property of MCM-41: Drug Delivery System
María Vallet‐Regí, A. Rámila, R. P. del Real et al. · Chemistry of Materials · 2000 · 2.2K citations