Functional Upregulation of the Vascular Endothelial Growth Factor Receptor KDR by Hypoxia

Abstract

These data indicate that hypoxia stimulates VEGF-dependent signaling not only by upregulation of VEGF ligand but also by functional upregulation of a specific signaling receptor. Therefore, these data provide evidence that the endothelium plays an active role in hypoxia-induced angiogenesis.