The enhancement of PCR amplification of a random sequence DNA library by DMSO and betaine: Application to in vitro combinatorial selection of aptamers

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations

Life Sciences, Biotechnology, Molecular Biology +12

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

Craig Tuerk, Larry Gold · Science · 1990 · 10.4K citations

Life Sciences, Microbiology, Molecular Biology +15

In vitro selection of RNA molecules that bind specific ligands

Andrew D. Ellington, Jack W. Szostak · Nature · 1990 · 9.7K citations

Life Sciences, Molecular Biology, Rna Processing +13

Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics

Sumedha D. Jayasena · Clinical Chemistry · 1999 · 2.1K citations · Full text

Pharmacy, Biomolecular Engineering, Molecular Biology +16

Betaine Improves the PCR Amplification of GC-Rich DNA Sequences

Wolfgang Henke, K. Herdel, Klaus Jung et al. · Nucleic Acids Research · 1997 · 523 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +10