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REACTIONS TO SKIN ALLOGRAFTS IN THE HORN SHARK, HETERODONTIS FRANCISCI
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1970
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HistocompatibilityImmunologyTissue TransplantationAnatomyDermatologyHeterodontis FrancisciTissue Rejection CapacityGraft SurvivalFish ImmunologyCell TransplantationTransplantation SurgeryXenotransplantationTransplantationTransplant ImmunologyBiologyHorn SharkNatural SciencesEvolutionary BiologyWound HealingMarine BiologyMedicineGraft Rejection
The tissue rejection capacity of the horn shark, Heterodontis francisci, was studied at 22 ± 1 C. This primitive elasmobranch requires several successive skin allograft challenges to attain an acute level of reactivity. Four successive sets of allografts showed median survival times of 41.1, 16.7, 9.3, and 7.4 days, respectively. First- and second-set allograft rejections were characterized mainly by slow melanophore cell destruction and mild inflammation. On the other hand, third- and fourth-set allograft rejections often resembled “white graft reactions,‘’ showing severe hemorrhage, hyperplasia, and poor healing. Such a progression from chronic to acute reactivity parallels the basic characteristics of weak histocompatibility systems, particularly the non-H-2 system of the mouse.