A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

Randall K. Saiki, Stephen J. Scharf, Fred Faloona et al. · Science · 1985 · 9K citations

Medicine, Genetics, Molecular Genetics +17

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

Masato Orita, Youichi Suzuki, Takao Sekiya et al. · Genomics · 1989 · 3.5K citations

Life Sciences, Genetics, Molecular Genetics +16

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

Paul L. Ludmer, Andrew P. Selwyn, Thomas Shook et al. · New England Journal of Medicine · 1986 · 2.4K citations

Medicine, Cardiology, Pharmacology +16

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

Joseph A. Vita, Charles B. Treasure, E G Nabel et al. · Circulation · 1990 · 1.2K citations · Full text

Medicine, Cardiology, Clinical Cardiology +12

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

Santiago Lamas, Philip A. Marsden, G.K. Li et al. · Proceedings of the National Academy of Sciences · 1992 · 989 citations

Life Sciences, Biochemistry, Molecular Biology +11