Animal Frontiers · 2015 · 23 citations · 72 references
Life SciencesGeneticsSystems BiologyGenomicsLivestock ProductionMulti-omics IntegrationData Preprocessing For OmicsGenomics IntegrationMulti-omics Data FusionOmics Data IntegrationOmics IntegrationPathway-based Omics IntegrationSystems Biology IntegrationSystems-level Genotype-phenotype Integration
Herd fertility is a key factor for the sustainability of cattle farming. However, declining fertility has become one of the main causes of culling and replacement of cows in developed countries. Omics technologies have been successfully developed in cattle, refining our knowledge of molecular mechanisms governing cattle reproduction. However, most studies have failed to establish clear links between the genome and final phenotypes. Further studies will be needed to integrate all Omics data and develop a systems biology modeling approach to tackle this complex biological function.
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Harmful recessive effects on fertility detected by absence of homozygous haplotypes
P.M. VanRaden, K.M. Olson, D.J. Null et al. · Journal of Dairy Science · 2011 · 341 citations · Full text
Divyaswetha Peddinti, Bindu Nanduri, Abdullah Kaya et al. · BMC Systems Biology · 2008 · 283 citations · Full text