Influence of single and multiple doses of amifostine on the efficacy and the pharmacokinetics of carboplatin in mice

Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.

John M. Yuhas · PubMed · 1980 · 294 citations

Medicine, Oncology, Pharmacology +17

cis-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II).

Fichtinger-Schepman Am, van Oosterom At, Lohman Ph et al. · PubMed · 1987 · 265 citations

Medicine, Molecular Biology, Oncology +14

Formation of DNA Adducts by the Anticancer Drug Carboplatin: Different Nucleotide Sequence Preferences in Vitro and in Cells

Frank A. Blommaert, Helma C. M. van Dijk-Knijnenburg, Fransje J. Dijt et al. · Biochemistry · 1995 · 146 citations

Medicine, Cancer Biology, Oncology +9

Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug.

Paula M. Calabro-Jones, José Aguilera, John F. Ward et al. · PubMed · 1988 · 143 citations

Life Sciences, Biochemistry, Cell Biology +16

Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects.

W. J. F. van der Vijgh, Godefridus J. Peters · PubMed · 1994 · 100 citations

Medicine, Oncology, Pharmacology +13