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The immediate vicinity of mouse metallothionein‐I gene contains two sites conferring glucocorticoid inducibility to the heterologous promoter

Sergey Plisov, Marina G. Nichiporenko, Alla L. Shkapenko, V.P. Kumarev, Ludmila V. Baranova, Tatyana I. Merkulova

FEBS Letters · 1995 · 13 citations · 16 references

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Abstract

Glucocorticoid responsive elements (GREs) located -252 to -209 by upstream and +1011 to +1054 bp downstream of the transcription initiation site of the mouse metallothionein-I (mMT-I) gene were identified in transient experiments. However, the promoter region of the mMT-I gene (-330 to +70 bp) was found to provide low, if any, glucocorticoid induction of the linked CAT gene, while showing strong cadmium regulation, comparable with the in vivo level.

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DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

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Diane M. Durnam, Richard D. Palmiter · Journal of Biological Chemistry · 1981 · 601 citations · Full text

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A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

Gary W. Stuart, Peter F. Searle, H Y Chen et al. · Proceedings of the National Academy of Sciences · 1984 · 406 citations · Full text

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