Genes encoding the Ti β subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression

Detection of specific sequences among DNA fragments separated by gel electrophoresis

E.M. Southern · Journal of Molecular Biology · 1975 · 32.8K citations

Chromatin, Dna Sequencing, Dna +15

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

Peter Rigby, Marianne Dieckmann, Carl Rhodes et al. · Journal of Molecular Biology · 1977 · 11.7K citations

Nucleic Acid Chemistry, High Specific Activity, Biochemistry +8

Efficient isolation of genes by using antibody probes.

R A Young, Ryan Davis · Proceedings of the National Academy of Sciences · 1983 · 2.1K citations · Full text

Engineering, Reverse Genetics, Genetics +18

Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

Ellis L. Reinherz, Patrick C. Kung, Gideon Goldstein et al. · Proceedings of the National Academy of Sciences · 1980 · 1.6K citations · Full text

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

Yusuke Yanagi, Yasunobu Yoshikai, Kathleen Leggett et al. · Nature · 1984 · 1.3K citations

Immunogenetics, Extensive Homology, Autoimmune Disease +9