Concepedia

Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1

Olivier Venier, Cécile Pascal, Alain Braun, Claudie Namane, Patrick Mougenot, Olivier Crespin, François Pacquet, Cécile Mougenot, Catherine Monseau, Bénédicte Onofri,

Bioorganic & Medicinal Chemistry Letters · 2011 · 14 citations · 30 references

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Concepts

References

30

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

Hiroaki Masuzaki, J. Paterson, Hiroshi Shinyama et al. · Science · 2001 · 1.8K citations

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11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

Yuri Kotelevtsev, Megan C. Holmes, Ann N. Burchell et al. · Proceedings of the National Academy of Sciences · 1997 · 855 citations

, , +17

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity

Eva Rask, Tommy Olsson, Stefan Söderberg et al. · The Journal of Clinical Endocrinology & Metabolism · 2001 · 638 citations

, , +17

Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2

Yuri Kotelevtsev, Roger Brown, Stewart Fleming et al. · Journal of Clinical Investigation · 1999 · 284 citations · Full text

, , +17

Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice

Pēteris Alberts, Linda Engblom, N. Edling et al. · Diabetologia · 2002 · 259 citations · Full text

, , +10