Concepedia

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

Marc Vermulst, Jonathan Wanagat, Gregory C. Kujoth, Jason H. Bielas, Peter S. Rabinovitch, Tomas A. Prolla, Lawrence A. Loeb

Nature Genetics · 2008 · 413 citations · 14 references

DOI

Concepts

References

14

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Aleksandra Trifunović, Anna Wredenberg, Maria Falkenberg et al. · Nature · 2004 · 2.7K citations

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Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

Gregory C. Kujoth, Asimina Hiona, Thomas D. Pugh et al. · Science · 2005 · 2.2K citations

, , +17

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

Samuel E. Schriner, Nancy J. Linford, George M. Martin et al. · Science · 2005 · 1.7K citations

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Andreas Bender, Kim J. Krishnan, Christopher M. Morris et al. · Nature Genetics · 2006 · 1.6K citations

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MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

AnthonyW. Linnane, Takayuki Ozawa, S Marzuki et al. · The Lancet · 1989 · 1.2K citations

, , +12