Total Synthesis of (−)-Lycorine and (−)-2-<i>epi</i>-Lycorine by Asymmetric Conjugate Addition Cascade

Abstract

Total syntheses of (-)-lycorine and (-)-2-epi-lycorine were accomplished using chiral ligand-controlled asymmetric cascade conjugate addition methodology, which enables the formation of two C-C bonds and three stereogenic centers in one pot to give synthetically useful chiral cyclohexane derivatives.