Asymmetric Synthesis Utilizing External Chiral Ligands

Abstract

This review examines some typical examples that illustrate the significant developments reported recently, in which external chiral ligands have been used as asymmetric controllers in stoichiometric and catalytic amounts. 1 . Introduction 2. Carbon-Carbon Bond Formation 2.1. Addition of Organometals to Aldehydes and Ketones 2.2. Addition of Organometals to α,β-Unsaturated Carbonyl Compounds 2.3. Alkylation of Enolates 2.4. Diels-Alder Reaction 2.5. Others 3. Deprotonation Using Chiral Lithium Amides 4. Oxidation 4.1. Epoxidation 4.2. Dihydroxylation 5. Reduction 6. Others 7. Conclusion