RNA Ligands That Distinguish Metabolite‐Induced Conformations in the TPP Riboswitch

Abstract

Molecular diversity meets RNA conformation: In vitro selected RNA hairpins (red) bind to the thiM riboswitch of E. coli and are released upon addition of thiamine pyrophosphate (TPP; see scheme). These hairpins guide the identification of nucleotides that are important for riboswitch function. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603166_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.