Effectiveness of mezlocillin and endotracheally administered sisomicin with or without parenteral sisomicin in the treatment of Gram-negative bronchopneumonia

Abstract

Two groups of ten comatose neurosurgical patients with aerobic Gram-negative bacillary bronchopneumonia, superimposed on tracheostomy or tracheal intubation, have been treated with systemic mezlocillin and endotracheally administered sisomicin, with or without systemic administration of the aminoglycoside. A similar clinical effectiveness was observed in both groups but, in one patient receiving systemic sisomicin, renal failure occurred. We concluded that for the therapy of Gram-negative bacillary infection of the bronchopulmonary tract in tracheotomized comatose patients, the systemic administration of aminoglycosides need not necessarily be added to endotracheal administration of aminoglycosides, when meziocillin is given systemically.