Stroke in young adults.

TLDR

Strokes in young adults are uncommon and often a diagnostic challenge. Young adults with stroke deserve an extensive but tailored evaluation, which should include angiography and echocardiography. The study was a retrospective review of 113 patients aged 15–45 admitted to the Medical Center Hospital of Vermont with stroke between 1982 and 1987. In this cohort, 8.5 % of all stroke admissions were young—a 2.3‑fold excess over national rates—with 41 % intracerebral hemorrhage (primarily aneurysms, AVMs, hypertension, tumors), 17 % subarachnoid hemorrhage (mostly aneurysms), and 42 % cerebral infarction (mainly cardiogenic emboli and premature atherosclerosis), and a 20.4 % case‑fatality rate versus 23.9 % nationally.

Abstract

Strokes in young adults are uncommon and often a diagnostic challenge. A retrospective study of strokes due to intracerebral hemorrhage, subarachnoid hemorrhage, or cerebral infarction was undertaken. We reviewed the medical records of 113 young patients aged 15-45 years who were admitted to the Medical Center Hospital of Vermont with a diagnosis of stroke between 1982 and 1987. This group comprised 8.5% of patients of all ages admitted for stroke, 2.3 times the proportion observed in the National Survey of Stroke. Nontraumatic intracerebral hemorrhage was diagnosed in 46 young patients (41%); the main causes included aneurysms, arteriovenous malformations, hypertension, and tumors. Subarachnoid hemorrhage was found in 19 young patients (17%); the majority were due to aneurysms. The remaining 48 young patients (42%) had cerebral infarction, the majority due to cardiogenic emboli and premature atherosclerosis. Mitral valve prolapse, the use of oral contraceptives, alcohol drinking, and migraine were infrequent sole causes of cerebral infarction in the absence of other risk factors. The case-fatality rate for this group of young patients with stroke was 20.4% compared with 23.9% for the National Survey of Stroke. Young adults with stroke deserve an extensive but tailored evaluation, which should include angiography and echocardiography.